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Abstract
This report delineates a case of extranodal NK/T-cell lymphoma, nasal type, in a 30-year-old Caucasian male. Presenting symptoms encompassed fatigue, weight loss, and the emergence of cutaneous lesions evolving from asymptomatic red nodules to painful ulcerated plaques. Laboratory assessments revealed profound abnormalities. Despite a prior dermatologic evaluation, including a punch biopsy indicative of atypical lymphocytic infiltrate, therapeutic interventions, such as methotrexate and antibiotics, failed to impede disease progression.
Pathological scrutiny of skin biopsies confirmed an angiocentric infiltrate, with immunohistochemistry demonstrating positivity for CD3, CD56, and EBV-encoded RNA, supporting the diagnosis of NK/T-cell lymphoma. Subsequent imaging illustrated extensive systemic involvement, including cardiac tamponade, myocardial infiltration, and gastrointestinal complications. Treatment efforts, encompassing chemotherapy, were met with limited success, ultimately culminating in the patient's demise.