Examining Current Use Cases of Botulinum Toxin to Manage Hyperhidrosis

Abstract

Hyperhidrosis is a sweat gland disorder characterized by the overproduction of sweat. Botulinum toxin is a neurotoxin produced from the Clostridium genus that inhibits the release of acetylcholine through deactivating cleavage of N-ethylmaleimide-sensitive factor attachment protein receptors. Periodic botulinum toxin injections are a common treatment for managing hyperhidrosis. A comprehensive literature search was conducted in PubMed using relevant keywords and MeSH terms investigating current botulinum toxin for hyperhidrosis management. Inclusion criteria includes manuscripts published exclusively in English and mandated the presence of a control group. Two independent reviewers will assess study eligibility based on predetermined criteria. Data extraction will cover study characteristics, participant demographics, treatment outcomes, and relevant findings. Thirty-one articles were identified that examined the effects of various botulinum toxin interventions in the management of hyperhidrosis. The different formulations of botulinum toxin showed varying efficacy, with botulinum toxin A prevailing as the cornerstone for hyperhidrosis treatment with botulinum toxin. The current literature shows extensive studies for the management of hyperhidrosis with botulinum toxin. Though the included studies showed promise in relief for the various forms of hyperhidrosis, more studies are needed to investigate the efficacy of botulinum toxin B for hyperhidrosis and longitudinal effects of all forms of botulinum toxin.